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Author

L. Villacorta

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Open access Sep 2026

X-inactivation escapee domains are CTCF-cohesin independent chromatin compartments

It is shown that facultative escape regions are self-sustaining compartments of active chromatin enriched in H3K27 acetylation and depleted in H3K27 methylation, with the magnitude of compartment strength scaling up with the degree of transcriptional activity on the inactive X chromosome.

Antonia Hauth, A. Loda, Nikolai S. Bykov et al. · 0 citations
Open access Aug 2026

High-resolution mapping of embryonic genome activation unveils a decoupling of transcription activation from precocious H3K4me3 removal

The results indicate that precocious removal of H3K4me3 from embryonic chromatin only modestly affects embryonic transcription without perturbing EGA timing, arguing against a major instructive role of precocious remodeling of maternally inherited H3K4me3 after fertilization on genome activation.

Jasmina Al-Mousawi, Luca Michetti, Laura Castaldi et al. · 1 citation · ⚡1

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