Aug 2026
Wnt signaling decline drives age-related alveolar stem cell loss and impairs lung repair
Tsotne Chitiashvili, Alexander L. Li, Agnieszka A. Wendorff et al.
· bioRxiv · 0 citations
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Open access
Jul 2026
Hypercapnia enhances airway smooth muscle contractility via STIM1-dependent Ca2+ signaling.
Hypercapnia, elevated carbon dioxide (CO2), is common in advanced chronic obstructive pulmonary disease (COPD) and predicts poor clinical outcomes. Traditionally considered a consequence of disease severity, hypercapnia may drive disease progression by promoting airway dysfunction. Here, we show that hypercapnia acts a...
M. Shigemura, Vitalii Kryvenko, Jennifer A. Pacheco et al.
· JCI Insight · 0 citations