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3e was found to have selective cytotoxic activity against cancer cells, which didn’t cause significant damage to non-cancerous cells, and may be effective on cancer patients without showing any side effects.
The novel 4‐aryl‐2‐hydrazinothiazole derivatives synthesized and evaluated for their anticancer activity in MCF‐7 breast cancer, A549 lung cancer, and L929 normal cell lines were found to exhibit high cytotoxicity, particularly showing more selective and high‐potential antiproliferative activity on the MCF‐7 cell line.
2‐thiazoline, a derivative containing 2‐thiazoline, which showed the most potential in terms of both anticancer and anti‐inflammatory activity among all compounds, was subjected to molecular docking studies on Caspase‐3 and COX‐1 enzymes and found to interact with the hydrophobic regions of amino acids.
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