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L. Zang

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Open access Oct 2026

THBS2 Marks Disease-Associated Chondrocyte States in Knee Osteoarthritis Cartilage: An Integrative Transcriptomic and Genetic Study

Background/Objectives: Knee osteoarthritis (KOA) is a major cause of disability, yet the molecular links between extracellular matrix (ECM) remodeling, focal adhesion signaling, and pathological chondrocyte state transitions remain incompletely defined. We aimed to identify focal adhesion-related molecules associated w...

Gang Hong, Bao-Dong Wang, Le Zhang et al. · 0 citations
Review Open access Oct 2026

Machine Learning and Deep Learning for the Diagnosis of Cervical Degenerative Diseases: Systematic Review and Meta-Analysis

Abstract Background Cervical degenerative diseases are a global public health issue, and their incidence is rising worldwide. Although an increasing number of studies on traditional machine learning (TML) and deep learning (DL) have been conducted in the detection and segmentation of cervical degenerative diseases and...

Hong-Wei Duan, Rui-Yuan Chen, Ming-Hui Liang et al. · 0 citations
Aug 2026

Comparison of the predictive roles of CT- and MRI-based endplate regional osteoporosis status measurements for cage subsidence after posterior lumbar interbody fusion.

Endplate HU values indicated a relatively higher predictive performance for CS compared with EBQ scores and served as the most discriminative BMD indicator in patients who underwent PLIF.

Peng Du, Ming-Hui Liang, Rui-Yuan Chen et al. · 0 citations
Review Open access Jul 2026

Diagnostic Performance of Large Language Models for Orthopedic-Related Rare Diseases and Their Impact on Physicians’ Diagnostic Accuracy: 2-Stage Comparative Evaluation Study Based on the Chinese Rare Disease Catalog

In the 2-stage LLM-assisted workflow, LLM assistance was associated with higher diagnostic correctness in both physician groups, although seniority-related differences in the magnitude of benefit require evaluation in larger studies.

Tusheng Li, Ziqian Ma, Baodong Wang et al. · 0 citations

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