La-Si Chen

Targeting the γ-glutamylcysteine-ferroptosis axis protects diabetic podocytes by dual-regulation of SAT1 and SLC7A11/GPX4

Diabetic kidney disease (DKD) remains the leading cause of end-stage renal disease worldwide, yet the mechanisms driving its progression are poorly understood. Here, through integrated multi-omics analyses of clinical serum samples and db/db mice, we identified a marked depletion of the glutathione biosynthetic inter...