Author

Lakshmanane Premkumar

3 papers indexed here

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Open access Oct 2026

A single dose of Dengvaxia is associated with transient reduction in dengue infection risk among dengue-naïve children

Dengvaxia ® induces antibody responses in dengue virus (DENV)-naïve children, but the durability of these responses and their impact on subsequent wild-type (WT) DENV infection remain unclear. Although previous studies have primarily evaluated vaccine efficacy against dengue disease, the impact of Dengvaxia ® on...

M. Abad-Fernández, J. Daag, L. D. Hein et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

A Zika Virus Vaccine with E Protein Fusion Loop Mutations Protects via CD8+ T Cells

There are currently no effective vaccines against Zika virus (ZIKV). Candidate vaccines target the ZIKV envelope (E) protein, the major target of anti-ZIKV neutralizing antibodies (nAbs). Here, we utilized DNA and RNA platforms to compare virus-like particle vaccines with premembrane (prM) and E expressed either in the...

Kantinan Chuensirikulchai, Qin-Hui Li, Hsueh-Han Lu et al. · Nature Microbiology · 0 citations

Open access Aug 2026

Severity-associated changes in ICOS, CD27, CD127 and CLA expression and expansion of virus-specific T Cells in acute dengue.

BACKGROUND Currently the role of dengue virus (DENV) specific T cell responses in disease pathogenesis and protection are not well understood, including potential differences in those who have obesity. We sought to investigate the functionality and phenotype of T cells in patients with acute dengue fever (DF) or dengue...

H. Kuruppu, M. De Silva, Chathumini Dissanayake et al. · Clinical and Experimental Im... · 0 citations