Lalaso Gaikwad

Synthesis and antiproliferative evaluation of thiophene-coupled azetidin-3-ylamino quinoline-3-carbonitrile derivatives

A novel series of (substituted)-1-methyl-2-oxo-4-(1-(thiophene-2-carbonyl)azetidin-3-ylamino)-1,2-dihydroquinoline-3-carbonitrile derivatives (5a–5m) was synthesized from substituted 2-aminobenzoic acids (1a–1g) via 1H-benzo[d][1,3]oxazine-2,4-diones (2a–2g). A straightforward route was established for the synthesis of...