Lama A. Hamadneh

Metabolic profiling reveals subtype-specific responses to jerantinine A acetate in breast cancer cells.

Jerantinines are natural indole alkaloids with promising anticancer activity in breast cancer cells via mechanisms of action involving tubulin binding and disruption of microtubule dynamics, with growth inhibition values, GI50 < 0.4 µM. However, metabolic responses of different breast cancer phenotypes are not yet unde...