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Lama Sleem

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Preprint Aug 2026

Comprehensive Benchmarking of Deep Learning Architectures for Lung Cancer Histopathology

Lung cancer remains the leading cause of cancer-related mortality worldwide, while histopathological diagnosis is often affected by inter-observer variability and the substantial workload associated with manual slide examination. Although deep learning has shown considerable potential in computational pathology, comprehensive benchmarks that integrate tissue classification and region segmentation within a unified analytical framework remain limited. This study presents a two-stage deep learning framework for multi-class tissue classification and pixel-level histopathological region segmentation, accompanied by a systematic comparison of state-of-the-art architectures at each stage. For tissue classification, six models, a custom convolutional neural network, VGG16, DenseNet, MobileNetV3, a custom Vision Transformer, and YOLO11, are evaluated on a combined dataset of 39,000 images derived from LC25000 and LungHist700. The models distinguish between adenocarcinoma, squamous cell carcinoma, and normal lung tissue. YOLO11 achieves the best classification performance, with an accuracy of 98.38%, a five-fold cross-validation accuracy of 98.21 +/- 0.35%, and a macro F1-score of 0.98. For region segmentation, U-Net, ResNet-encoder U-Net, DeepLabV3+, and YOLO11-seg are evaluated using the GlaS gland segmentation benchmark. DeepLabV3+ obtains the highest Intersection over Union of 0.80 and a Dice score of 0.89, while YOLO11-seg achieves a comparable Intersection over Union of 0.79 using approximately 14x fewer parameters. The best-performing classification and segmentation models are subsequently integrated into an end-to-end framework, providing an accurate, computationally efficient, and reproducible baseline for automated histopathological image analysis.

Hadi Hasan, Safaa Salman, Lama Sleem et al. · 0 citations
Conference Jul 2026

PRISM: A Lightweight Method for Jailbreak Detection via Prompt-Response Semantic Coherence Scoring in LLMs

Detecting whether a jailbreak attack against a large language model (LLM) has succeeded is a challenging problem in AI security. Existing approaches rely on brittle string matching, expensive LLM-based judges, or task-specific classifiers that often fail to generalize. This paper investigates whether semantic coherence is sufficient to evaluate jailbreak success. In this work, we propose PRISM: Prompt-Response coherence for Identifying jailbreaks via Scoring Method, a lightweight method that models jailbreak detection as a coherence problem between the harmful prompt and the model response. The approach combines multiple semantic similarity signals within an ensemble of classical and simple machine learning models. Training in 3,480 pairs of prompt-responses from AdvBench, HarmBench and Alpaca, PRISM achieves F1 = 0.91 and AUC-ROC = 0.98 in the internal test set. In a held-out validation set of 694 labeled samples never seen during training, it outperforms six baseline attack success estimators, achieving the highest accuracy (0.746) and AUC-ROC (0.840), while being up to $\mathbf{1 6} \times$ faster than LLM-based methods. These results demonstrate that semantic coherence provides a robust and efficient signal for jailbreak detection, significantly reducing the implementation complexity of state-of-the-art approaches.

Costabile Di Gregorio, Lama Sleem, Jérôme François et al. · 0 citations