Author

Lan Huang

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Open access Sep 2026

A Meiotic B-type Cyclin Selectively Drives Mitotic Progression and Fidelity in Cancer Cells

Cell cycle transitions are driven by cyclins in complex with cyclin-dependent kinases (CDK). Here, we demonstrate that cyclin B3, an evolutionarily divergent B-type cyclin previously thought to function exclusively in female meiosis, is expressed in mitotic cells and interacts with both CDK1 and CDK2. We show that cycl...

Amrutha Kizhedathu, Anh Cao Ngoc Nguyen, Clinton Yu et al. · bioRxiv · 0 citations

Aug 2026

Mapping interaction of assembly factor Rpn14 with the proteasome base reveals a bipartite interface and implies ordered remodeling of intersubunit contacts during proteasome biogenesis.

The 26S proteasome is the largest known protease and an essential mediator of targeted protein degradation, a transformative therapeutic modality for human diseases. Assembly of the 26S proteasome from its 66 cognate subunits depends on nine dedicated assembly chaperones. These chaperones generally function by stabiliz...

Quill Thomas, Madison Sterling, Lauren G. Carnley et al. · Journal of Molecular Biology · 0 citations

Open access Jul 2026

Integrated Interactomics Reveals Novel Protein Associations: The FOXA1-PBX1 Complex as a Case Study

It is proposed that the FOXA1-PBX1 complex could represent a higher-order regulatory node integrating chromatin accessibility and ER-driven transcriptional output, and functional enrichment analyses showed strong convergence on coherent biological pathways.

Zhi Chen, Istvan Szepesi-Nagy, Qing-Yue Zhang et al. · bioRxiv · 0 citations