Open access
Oct 2026
GCF-anchored and target-oriented mining of metagenomic BGC space for bioactive product discovery
ABSTRACT Microbial natural products are vital for drug discovery, yet pervasive genomic fragmentation and data volume hinder the translation of metagenomic biosynthetic gene clusters (BGCs) into therapeutic leads. We present metasynBGC, a target-oriented framework that employs a “function-first” logic using experimenta...
Xiao Yang, Jia-Cheng Wu, Tao Wang et al.
· Microbiology spectrum · 0 citations