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Author

Lan Zhang

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Jul 2026

Metabolic flux reprogramming and protein engineering drive efficient l-arginine biosynthesis.

An enzyme-constrained model was used to identify 11 gene targets affecting l-arginine production and engineered the rate-limiting enzyme argininosuccinate synthetase to construct the strain Arg11, achieving the best performance reported to date.

Shengyang He, Qi Sheng, Gang Men et al. · 0 citations
Open access Jul 2026

Systems metabolic engineering of Corynebacterium glutamicum for efficient production of L-isoleucine

L-Isoleucine is an essential branched-chain amino acid for livestock and poultry, supporting protein accretion and regulating energy metabolism, immune function, and stress resilience. A genetically stable L-isoleucine producer, Corynebacterium glutamicum cgl-Ile0, was obtained via biosensor-assisted ARTP mutagenesis,...

Junkun Cao, Ming Huang, Qi Sheng et al. · 0 citations

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