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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Lang Jiang

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2 papers indexed here

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Open access Sep 2026

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

ABSTRACT Sepsis‐induced acute lung injury (ALI) is a lethal inflammatory condition with limited therapeutic options. Macrophage autophagic homeostasis is essential to constrain septic ALI inflammation, though its upstream regulation remains elusive. Here, we report that lysosomal‐associated protein transmembrane 5 (LAP...

Lang Jiang, Qi-Lan Li, Hao Liu et al. · 0 citations
Open access Sep 2026

Targeting the AKT2-NAMPT phosphorylation axis prevents macrophage senescence to enhance bactericidal activity in septic immunosuppression.

A dual-layer regulatory mechanism in which DDX6 controls NAMPT abundance, whereas AKT2 dictates its activity drives senescence during immune tolerance is identified, identifying AKT2-NAMPT as a potential therapeutic axis to restore immune competence in sepsis.

Qi-Lan Li, Mei He, Pei-Lin Shi et al. · 0 citations

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