Author

Lanuza A. P. Faccioli

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Open access Oct 2026

YY1 phosphorylation links non-apoptotic caspase-8 signaling to MASH fibrosis

Background & Aims Metabolic dysfunction-associated steatohepatitis (MASH) is a leading cause of chronic liver disease, and liver fibrosis is the principal determinant of disease progression and clinical outcome. We recently showed that non-apoptotic caspase-8 in hepatocytes is upregulated in MASH and leads to the induc...

Xiao-Bo Wang, Eui-Jung Jung, Lanuza A. P. Faccioli et al. · bioRxiv · 0 citations

Open access Sep 2026

Liver disease reveals KIF12 as a regulator of mitochondria, lysosome and cilia localisation in human cholangiocytes

Summary Background Rare bi-allelic mutations in kinesin family member 12 (KIF12) cause high gamma-glutamyl transferase (GGT) cholestatic liver disease, yet the cellular mechanisms driving this phenotype remain unknown. Methods To investigate the role of KIF12 in biliary pathology, we introduced the homozygous p.Arg219∗...

Anubha Seth, Joseph Brancale, Nina Dashti-Gibson et al. · EBioMedicine · 0 citations