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Author

Lara C. Busby

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Open access Oct 2026

Reciprocal coupling between EMT and BMP morphogen signalling drives collective cell invasion.

During collective cell invasion, epithelial-to-mesenchymal transition (EMT) and morphogen signalling-mediated cell fate specification are traditionally viewed as a linear cascade: morphogens drive cell fates that activate EMT gene expression programs. Here, we uncover reciprocal coupling between EMT initiation and BMP...

Y. Takahashi, Alexandra Neaverson, Lara C. Busby et al. · 0 citations
Open access Aug 2026

Ectomesenchymal identity emerges via relief of Twist1 transcript destabilisation

During vertebrate development, a subset of cranial neural crest cells (CNCCs) termed ‘ectomesenchyme’ differentiates into cell types canonically associated with the mesoderm (cartilage, bone and muscle). While the molecular decisions that guide CNCCs toward ectomesenchymal identity remain incompletely understood, the t...

Lara C. Busby, Jessica R. Patrick, Luke W. Lyons et al. · 0 citations

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