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Author

Larissa Traxler

2 papers indexed here

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Open access Sep 2026

Autophagy Flux Is Remodeled Sex‐ and Cell Type‐Specifically During Human Aging, and Is Linked to Reduced Physical Function in Older Adults

ABSTRACT Autophagy is widely proposed to decline with age; however, direct evidence across human cell types remains limited. Moreover, it is unclear whether age‐associated changes in autophagy‐gene transcription are accompanied by corresponding changes in autophagic activity, and whether autophagic activity relates to...

Tatiana M. Moreno, Stephanie R. Heimler, Ryan J. Moran et al. · 0 citations
Open access Oct 2026

Nuclear acetyl-CoA accumulation drives reversible RBP hyperacetylation and transcriptome-wide splicing shifts in age-equivalent Alzheimer’s disease neurons

Metabolic alterations and dysregulated alternative RNA splicing are central layers of Alzheimer’s disease (AD) pathogenesis, yet whether and to what extent these changes are mechanistically linked in adult human neurons in the aging brain remains unclear. To assess this, we generated induced neurons (iNs) by direct con...

Larissa Traxler, Oliver Borgogno, Kylie Champion et al. · 0 citations

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