Lars J. Dornfeld

Joint protein, mRNA and DNA sequence design and optimization with nucleotide-level Potts models

Protein design typically generates amino acid sequences first and then translates them into DNA post-hoc limiting control over the nucleotide sequence via codon choice at design time. We introduce NuCaliby, a structure-conditioned model that jointly designs amino acid, mRNA, and DNA sequences of a protein at nucleotide...