Open access
Sep 2026
The rapid delivery of RNase H variants reveals distinct classes of RNA:DNA hybrids
Multiple lines of evidence suggest that RNase H1-sensitive RNA:DNA hybrids (thereafter referred to as ‘hybrids’) could disrupt the stability and restart of stalled replication forks. The prolonged over-expression of RNase H1 is the most popular method to manipulate hybrids in situ but it cannot discriminate between dir...
Amandine Basille, Yara Bawadi, Yea-Lih Lin et al.
· bioRxiv · 0 citations