Glycopeptide-based classification of erythropoietin biopharmaceuticals by microseparation techniques coupled to mass spectrometry and multivariate analysis.
In the present study, a bottom-up approach was followed to characterize three recombinant human erythropoietin (rhEPO) biopharmaceuticals: two commercially available drugs (EPO cim and EPO crs) and one currently under clinical evaluation for neurodegenerative diseases (NeuroEPO plus). After tryptic digestion, the resul...