Author

Laurel A. Grisanti

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Open access Oct 2026

Novel 5-Phenylmorphans as Opioid Receptor Antagonists: Synthesis, Structure-Activity Relationship, Biological Evaluation and Computational Modeling

The widespread emergence of ultra-potent synthetic opioids in illicit drug supplies and the limited effectiveness of naloxone in reversing certain synthetic opioid overdoses highlight the urgent need for potent high-affinity opioid antagonists. This study describes an improved synthetic approach and structure-activity...

Z. Hasanpour, Dan Luo, T. Prisinzano et al. · Molecules · 0 citations

Beyond clinical variables: Machine learning integration of clinical and contextual factors for predicting heart failure readmissions

This study used machine learning to integrate clinical and socioeconomic factors to improve prediction accuracy in heart failure patients and found that on the test set, random forest and XGBoost outperformed logistic regression.

Abdullah al Marrawi, F. Alahdab, Faha Facc et al. · 0 citations