Laurence Hugueny

Multimodal circadian phenotyping reveals distinct mechanisms of photic entrainment failure in two sighted patients with non-24-hour sleep-wake disorder.

This first multimodal characterization of sighted N24SWD reveals distinct pathophysiological mechanisms underlying failure of photic circadian entrainment and suggests that N24SWD in sighted individuals should not be considered a unitary disorder but rather a heterogeneous condition resulting from dysfunction at different levels of the circadian photic entrainment pathway.