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Author

Lawrence D. Harris

2 papers indexed here

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Open access Oct 2026

Nucleoside analogs containing an imino-ribitol sugar exhibit a distinctive pattern of interference with RNA synthesis by the Dengue virus polymerase.

Iminovirs are antiviral nucleoside analogs in which the naturally occurring ribose sugar is replaced by an imino-ribitol group, linked to the base by a non-native carbon-carbon bond. The prototypical iminovir is galidesivir, an adenosine analog that inhibits replication of a wide range of RNA viruses. Initial investiga...

S. Deshpande, Anthony J. B. van Hameren, James M. Wood et al. · 0 citations
Open access Sep 2026

The antiproliferative and pro-apoptotic effects of 3-deoxy-3α-fluoro-chenodeoxycholic acid and 12β-methyl-3,7-dioxo-17-epi-25-homo-18-nor-5β-cholan-25-oic acid on human breast cancer cell lines.

Bile acid derivatives have emerged as promising candidates in cancer therapeutics due to their ability to modulate key cellular signalling pathways, including those involved in apoptosis, cell cycle regulation, and inflammation. Structural modifications of natural bile acids have been shown to enhance their cytotoxicit...

Divyashree Ravishankar, Joseph M. Watts, A. Luxenburger et al. · 0 citations

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