Atherosclerosis remains a leading cause of cardiovascular mortality, driven by macrophage dysfunction and necrotic core expansion. Ferroptosis, an iron-dependent cell death, is a critical driver of plaque instability; however, pharmacological interventions targeting ferroptosis remain scarce. Lentinan (LNT), a bioactiv...
Metabolic remodeling, defined as changes in the energy substrate preferences and energy production efficiency of the myocardium, is one of the pathogenic characteristics of failing hearts, though its molecular mechanisms remain incompletely understood. Through untargeted metabolomics coupled with targeted mass spectrom...
Hong-Tu Cui, Lu Fang, Huan-Huan Cao et al.· Science China Life Sciences· 0 citations
The value of MODPM lies not in stacking additional data layers but in building a multiscale, continuously learnable framework to link biological heterogeneity to clinically interpretable and actionable decisions.
