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Le-Ping Zhang

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Case report Open access Aug 2026

Case Report: Wolman disease caused by LIPA variants in two Chinese infants and a focused literature synthesis

Background Wolman disease is the severe infantile form of lysosomal acid lipase deficiency, caused by biallelic pathogenic variants in the Lysosomal Acid Lipase (LIPA) gene. It is rapidly progressive and often fatal within the first year of life without disease-specific therapy. Because early manifestations are non-spe...

Le-Ping Zhang, Qiong Yu, Xinjing Ge et al. · 0 citations
Oct 2026

Rapid Manufactured CAR-T Cells enriched for CD45RA-negative T cells Exhibit Superior Persistence Compared to Conventional CAR-T Therapy.

CD19 CAR-T has achieved high remission rates in relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). However, rapid generation with durable in vivo persistence remains a major challenge. CD45RA-negative T cells exhibit sustained antileukemic activity and preserved immune memory. Here, we developed a rapid p...

Xu-Ying Pei, Meng Lv, Xiao-Zheng Zhao et al. · 0 citations

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