Author

Le Yang

3 papers indexed here

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Sep 2026

Berbamine Alleviates Chronic Inflammatory Pain via Microglial Inhibition and Oxidative Stress Reduction in the Anterior Cingulate Cortex.

Chronic pain, defined as persistent pain lasting beyond three months, imposes a severe burden on patient quality of life. Berbamine (BBM), a natural bisbenzylisoquinoline alkaloid with anti-inflammatory and antioxidant properties, is a promising candidate for pain management, although its analgesic mechanism remains un...

Yan Qin, Jing-Yue Yao, Yu-Hua Wang et al. · European Journal of Pharmaco... · 0 citations

Sep 2026

Baicalein-loaded procyanidins nanoparticles alleviate neuroinflammation in Parkinson's disease by restoring microglial 8-oxoguanine DNA glycosylase 1.

Microglial NLRP3 inflammasome activation and M1 polarization, driven by unresolved 8-oxoguanine (8-oxoG) DNA damage resulting from downregulated 8-oxoguanine DNA glycosylase 1 (OGG1), are key drivers of neuroinflammation in Parkinson's disease (PD). Baicalein (BAI) can restore OGG1 and interrupt this pathological cycle...

Hong-Yan Zhou, Yan-Feng Song, Ying Gao et al. · Journal of Controlled Releas... · 0 citations

Open access Jun 2026

Cimifugin alleviates chronic inflammatory pain by inhibiting neuroinflammation and restoring synaptic function: A network pharmacology and in vivo study

Background Chronic inflammatory pain has a high incidence, and existing drugs have side effects. The natural product Cimifugin has anti-inflammatory and analgesic potential, but its role and mechanism in treating chronic inflammatory pain remain unclear. This study aims to explore the potential targets, signaling pathw...

Han-Yu Lei, Zheng Rong, Guan Liu et al. · Molecular Pain · 0 citations