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Author

Le Yuan

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Aug 2026

The loss of aars1 in zebrafish increases tolerance to hypoxia by reducing hif1α degradation via the autophagy-lysosome pathway.

Alanyl-tRNA synthetase 1 (AARS1) has been identified as an enzyme that can recognise L-lactate directly and function as a lactyltransferase. However, its potential regulatory role in hypoxia tolerance remains unclear. In this study, we generated aars1 mutants in zebrafish using the CRISPR/Cas9 technique. We found that...

Ya-Nan Song, Zhi Li, Le Yuan et al. · 0 citations

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