Open access
Jul 2026
Non-canonical signaling hubs upon inhibition of MyD88-ERK interaction in cancer
The RAS-MAPK pathway is frequently dysregulated in cancer, leading to malignant transformation. We previously identified a direct interaction between MyD88, a central adaptor of inflammatory signaling, and ERK, the terminal kinase of the RAS-MAPK cascade. Pharmacologic disruption of this ERK-MyD88 complex with a small...
Nader Hussein, Najwa Skafi, Thuy Ha Pham et al.
· Cell Death and Disease · 0 citations