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Lee-Wei Yang

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Open access Oct 2026

Development of A10P3C, an isoform-selective inhibitor of EGLN2, for targeting breast cancer.

Oxygen sensing signaling is mainly mediated by EGLN prolyl hydroxylases, which plays important roles in physiology and diseases. Among them, EGLN2 plays an oncogenic role in breast cancer. However, the development of isoform-selective EGLN2 inhibitors remains a major challenge. Here, we report the identification of A10...

Qian Liang, Hui-Min Zhu, Ban-Chieh Huang et al. · 0 citations
Open access Jul 2026

Drug Functional Site-Unknown Molecular Targets Exemplified by SARS-CoV-2 pseudoknot and ribosomal frameshifting-modulators

This framework establishes a generalizable strategy for rationally targeting structured RNAs with repurposed drugs and offers new opportunities to expand the druggable genome to include noncoding RNA elements and other biomolecular targets lacking known functional sites.

A. Ragab, C. L. Ortiz, Yu-Tong Huang et al. · 0 citations

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