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Author

Leena M. Abdelrahman

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Oct 2026

Metabolic reprogramming of pathogenic CD4+ T helper cells attenuates inflammatory bowel disease in mice.

CD4+ effector T helper 1 (TH1) cells drive inflammatory bowel disease (IBD). Here, we investigated how integrated signaling, metabolic, and epigenetic programs sustain their pathogenic persistence. We found that enforcing mitochondrial pyruvate metabolism with methyl pyruvate (MePyr) suppressed TH1 cell effector functi...

Shravan K. Mishra, Leena M. Abdelrahman, Hyun Se Kim Lee et al. · 0 citations

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