Review
Open access
Sep 2026
Itaconate and its derivatives in human health and diseases
Metabolic reprogramming forms the foundation of immune effector functions and the regulation of inflammation. As a pivotal node connecting the tricarboxylic acid cycle to immune signaling, the IRG1/ACOD1 and itaconate axes play a central role in coordinating inflammatory tone and redox balance. Itaconate, generated thr...
Jian-You Gu, Wen-Ying Zhang, Jun-Feng Zhang et al.
· Signal Transduction and Targ... · 0 citations