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Lei-Han Zhang

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Review Open access Sep 2026

Tau phosphorylation in Alzheimer’s disease: emerging mechanisms, network interactions, and therapeutic implications

While amyloid-β (Aβ) has historically dominated the research landscape of Alzheimer’s disease (AD), the limited clinical success of Aβ-centric therapies has redirected focus toward tau pathology, which correlates more robustly with cognitive deterioration and synaptic dysfunction. Transcending the traditional linear...

Xue Li, Lei-Han Zhang, Li-Jun Zhao et al. · 0 citations

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