Author

Lei Jin

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Open access Aug 2026

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of...

Liang Xu, Wanying Xiang, Xinyue Wang et al. · Advancement of science · 0 citations

Open access Aug 2026

p38β-mediated BiP phosphorylation drives stemness and chemoresistance by suppressing UPR activation in hepatocellular carcinoma

It is discovered that p38β/MAPK11 phosphorylation of BiP promotes stemness and chemoresistance in HCC, revealing a targetable p38β–BiP axis in HCC.

Liang Xu, I. B. Huang, Minghe Zhang et al. · Nature Communications · 0 citations