Neutrophil extracellular traps delivering lactylated S100a9 aggravate neuronal cuproptosis by regulating Ttr/Commd1/Atp7b axis after traumatic brain injury.
Traumatic brain injury (TBI) is a leading cause of disability and mortality, with secondary injury mechanisms involving neuronal death and neuroinflammation, for which effective treatments remain limited. Neutrophil extracellular traps (NETs) are implicated in post-TBI neuropathology. Cuproptosis, a copper-dependent ce...