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Author

Lei Ma

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Open access Sep 2026

Haematological toxicity associated with antineoplastic drugs: a pharmacovigilance analysis based on the FDA adverse event reporting system database

A retrospective pharmacovigilance study using FAERS data covering the period from 2004 Q1 to 2025 Q4 reveals a strong signal of haematological toxicity associated with antitumour agents, supporting enhanced routine monitoring to mitigate clinical risks.

Xing-Nong Xu, Lei Ma · 0 citations
Aug 2026

Novel VHL ligand-based PROTACs targeting JNK1: design, synthesis, and biological evaluation with potent anti-EMT activity.

This work describes the design, synthesis, and biological evaluation of a series of JNK1-targeting PROTACs that recruit either CRBN or VHL E3 ligases that demonstrates excellent degradation potency and selectivity for JNK1, highlighting its potential as a valuable chemical probe for EMT-associated pathologies.

Shuhua Ren, Ye Zhang, Rui Hao et al. · 0 citations

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