Author

Lei Sun

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Open access Oct 2026

DeCoRE: A computational method to resolve RNA structural heterogeneity from RNA structure probing data by direct RNA sequencing

RNA molecules are inherently dynamic, forming complex structural ensembles of alternative conformations that direct their cellular functions. Current methods for resolving RNA structural heterogeneity and dynamics have been developed for short-read sequencing–based structure probing, limiting their sensitivity and reso...

Yong Huang, Jin-Song Zhang, Lei Sun et al. · Science Advances · 0 citations

Open access Sep 2026

ER‐Localized Deadenylase PNLDC1 Suppresses Colorectal Cancer Progression by Targeting the mRNA Decay of TUBB4B

ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality, highlighting the urgent need for novel therapeutic strategies. In this study, we find that PARN‐like Domain Containing protein‐1 (PNLDC1), an endoplasmic reticulum‐localized deadenylase, lower expresses in 91 clinical CRC tissues. Usi...

Le-Xin Liu, Yue-Lin Guan, Yu-Zhou Qin et al. · Exploration · 0 citations

Open access Oct 2025

Modtector: ultra-fast modification signal mining on mapped sequencing reads

Summary Current tools for RNA epitranscriptomic modification and structural feature analysis are often fragmented, focusing on single signal types and struggling with processing efficiency, especially as sequencing data volumes increase and single-cell technologies advance. To address this challenge, we developed Modte...

Tong Zhou, Yifan Hong, Panfeng Li et al. · bioRxiv · 1 citation