Conventional single-target drugs frequently suffer from limited efficacy and drug resistance. Here, we report an amphiphilic peptide dendrimer that integrates intrinsic bioactivity and nanocarrier functions, establishing a novel “drug-bioactive carrier” paradigm for multi-target cancer therapy. Using reverse molecula...
Yuan-Zheng Huang, Chong-Qing Pan, Bao-Ping Lian et al.· Journal of Medicinal Chemist...· 0 citations
These studies highlight the expanding scope of proximity-induced phosphorylation control, while emphasizing that broader application will depend on improved molecular design and a clearer understanding of proximity-driven mechanisms.
Yuxin Xia, Daichao Zhai, Qi-Dong You et al.· RSC Medicinal Chemistry· 0 citations
Covalent inhibitors bind tightly and persistently to protein targets via covalent links with nucleophilic amino acids, yet unintended covalent modification of irrelevant proteins creates major safety risks and restricts their clinical use. To tackle this issue, researchers have shifted from reactivity-centered design t...
Shang-Jun Bai, Meng-Han Gao, Qi-Dong You et al.· European journal of medicina...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.