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Sep 2026

Discovery of an HSP90-Modulating Amphiphilic Peptide Dendrimer as a Bioactive Carrier for Combination Cancer Therapy

Conventional single-target drugs frequently suffer from limited efficacy and drug resistance. Here, we report an amphiphilic peptide dendrimer that integrates intrinsic bioactivity and nanocarrier functions, establishing a novel “drug-bioactive carrier” paradigm for multi-target cancer therapy. Using reverse molecula...

Yuan-Zheng Huang, Chong-Qing Pan, Bao-Ping Lian et al. · 0 citations
Review Open access Aug 2026

Modulating phosphorylation by proximity-inducing strategy: an update.

These studies highlight the expanding scope of proximity-induced phosphorylation control, while emphasizing that broader application will depend on improved molecular design and a clearer understanding of proximity-driven mechanisms.

Yuxin Xia, Daichao Zhai, Qi-Dong You et al. · 0 citations
Review Sep 2026

Precision covalent chemistry: Advances in selectivity-driven covalent drug design over the past five years.

Covalent inhibitors bind tightly and persistently to protein targets via covalent links with nucleophilic amino acids, yet unintended covalent modification of irrelevant proteins creates major safety risks and restricts their clinical use. To tackle this issue, researchers have shifted from reactivity-centered design t...

Shang-Jun Bai, Meng-Han Gao, Qi-Dong You et al. · 0 citations

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