Open access
Sep 2026
Systematic CRISPRi perturbation of 1,408 autism risk genes maps multilevel transcriptional convergence in human cortical neurons
A CRISPRi Perturb-seq screen targeting 1,408 ASD risk genes in human embryonic stem cell-derived immature cortical neurons is performed and the resulting transcriptomic effects by single-cell RNA sequencing are profile by single-cell RNA sequencing.
Ashlesha Gogate, Wei-Chen Chen, Mpathi Nzima et al.
· bioRxiv · 0 citations