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Open access Sep 2026

Enhanced CD33 CAR-NK cells secreting anti-CD73scFv overcome adenosine-mediated immunosuppression and improve anti-AML efficacy

The CD33-CD73 dual-targeting CAR-NK platform synergistically targets AML cells and the adenosine-rich TME, exhibiting superior anti-leukemia efficacy and provides a translational blueprint for TME-targeted therapies in other cancers.

Lu Wang, S. Gong, Jun Wang et al. · 0 citations

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