Author

Lei Xu

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#diffusion models Open access Sep 2026

scLDM: a conditional diffusion framework for single-cell perturbation prediction.

MOTIVATION Accurate prediction of single-cell responses to external stimuli is pivotal for deciphering gene regulatory mechanisms and accelerating data-driven drug discovery. However, effectively capturing the complex, non-linear mapping between intrinsic cell states and external stimuli remains an open problem. RESU...

Bo-Yang Wu, Yu-Hang Liu, Yue Cheng et al. · Bioinformatics · 0 citations

Sep 2026

Deciphering T-cell receptor-antigen recognition through interpretable residue-level interaction modeling.

Accurate identification of interactions between T-cell receptors (TCRs) and antigenic peptides presented by major histocompatibility complex (MHC) molecules is essential for advancing precision immunotherapy. However, existing approaches often exhibit limited generalization to unseen peptides and struggle to capture th...

Wen-Yu Xi, Ruheng Wang, Xiu-Cai Ye et al. · International Journal of Bio... · 0 citations