Author

Lei Zhang

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Sep 2026

A Ubiquinone-Reactive Pt(IV) Prodrug Perturbs Mitochondrial Metabolism for Selective Tumor Suppression.

Pt(IV) prodrugs offer a versatile platform for the design of platinum-based antitumor drugs; yet utilizing axial ligands to actively modulate tumor bioenergetics has been less investigated. Herein, we report a mitochondria-directed Pt(IV) prodrug, LA-Pt(IV), in which lipoic acid (LA) serves as a metabolite-reactive axi...

Yi Dai, Wen-Xin Yu, Yi-Chen Yin et al. · ACS Applied Bio Materials · 0 citations

Open access Jul 2026

Bioinformatics-based identification of glycolysis-related signatures associated with drug resistance and prognosis in lung adenocarcinoma

It is suggested that glycolytic activity is closely associated with both drug resistance and clinical prognosis in LUAD, and the proposed integrative model holds promise for enhancing precision treatment decision-making through optimized risk assessment and rational selection of chemotherapeutic regimens.

Qian Zheng, Yunxiao Liu, Tianli Li et al. · Frontiers in Oncology · 0 citations