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Author

Lei Zhang

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Aug 2026

Prevalence of High Tumor Mutational Burden Among Pediatric Patients With Solid Tumors.

High tumor mutational burden (TMB-H), defined as ≥10 non-driver somatic mutations per mega base of genome sequenced (mut/Mb), and high microsatellite instability (MSI-H), which can lead to TMB-H, are both associated with response to the immunotherapy pembrolizumab. Data from the KEYNOTE-158 study demonstrated that the...

Wen-Jun Zhong, E. Dettman, Lei Zhang et al. · 0 citations
Open access Jan 2026

Integrated Bulk and Single‐Cell Transcriptomic Analyses Identify a Five‐Gene Signature Associated With Prognosis and the Tumor Microenvironment in Epstein–Barr Virus–Associated Gastric Cancer

Background Epstein–Barr virus–associated gastric cancer (EBVaGC) is a distinct molecular subtype of gastric cancer, but reliable biomarkers linking EBV‐related biology, prognosis, and microenvironmental remodeling remain limited. Methods Differentially expressed genes associated with EBVaGC were identified from TCGA an...

Luyu Jin, Man Jiang, Yu-Long Pan et al. · 0 citations

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