Getah virus (GETV) is an emerging mosquito‐borne zoonotic alphavirus that poses a threat to multiple animal species, particularly pigs, and carries significant public health implications. Nevertheless, the molecular evolution and pathogenicity of circulating GETV strains in China remain incompletely defined. In this st...
Zhao-Ying Xiang, Xing-Chen Wang, Yuchen Huang et al.· Transboundary and Emerging D...· 0 citations
Introduction The African swine fever virus (ASFV) viroporin pB169L is a conserved membrane protein, but well-defined reagents for its detection and molecular characterization remain limited. Methods A soluble recombinant antigen comprising the non-transmembrane regions of pB169L was used to generate a mouse monoclonal...
Zhi-Ying Cui, Jia-Ning Feng, Miao-Miao Ye et al.· Frontiers in Microbiology· 0 citations
The first identification of a natural GETV variant isolated from the brain of diseased piglets is reported, identifying a highly conserved E1 stem motif as a critical regulator of GETV virulence, offering a strategic target for developing attenuated vaccines against GETV and other alphaviruses.
Zhao-Ying Xiang, Gan-Bo Li, Jia-Yi Wang et al.· Virulence· 0 citations
In vitro findings reveal that ASFV dismantles host phagolysosomal acidification, thereby neutralizing the microbicidal potential of infected macrophages and potentially converting them into a permissive niche for secondary bacterial pathogens.
The evidence of PRRSV 1 and PRRSV 2 concurrent circulation in the single sow farm in China is provided, which highlights the ongoing evolution of both Chinese PRRSV species and underscores the urgent need for enhanced surveillance and updated control strategies.
Zhendong Zhang, Di Gao, Zihe Wang et al.· Virulence· 1 citation· ⚡1
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