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Leila Caroline Souza Reis

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Review Open access Oct 2026

Efficacy of immune-oncology combinations versus sunitinib in patients with bone metastases from renal cell carcinoma: A systematic review and meta-analysis of phase III trials with long-term follow-up

Background Bone metastases occur in approximately one-third of patients with metastatic clear-cell renal cell carcinoma (ccRCC) and are associated with poor prognosis. Although immune-oncology (IO)-based combinations are the standard first-line treatment, the relative efficacy of IO plus tyrosine kinase inhibitor (IO+T...

C. F. A. de Albuquerque, Leila Caroline Souza Reis, E. Del Fiol Manna et al. · 0 citations

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