Author

Lenore J. Cowen

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Open access Aug 2026

MiLaSol: modeling protein solubility by mixing up multiple protein language models

This work presents a computational method to reengineer insoluble protein variants into soluble forms, with predictions confirmed by multiple independent solubility prediction methods, and demonstrates the effectiveness of combining machine learning-based solubility prediction with generative optimization for protein e...

Weiwei Lou, M. Erden, Lenore J. Cowen · Bioinformatics Advances · 0 citations

Open access Jul 2026

Comprehensive Mapping of Immune Nanobody Repertoires with NanoMAP 2267451

Nanobodies have recently emerged as an alternative to classical antibodies in therapeutic and diagnostic contexts, promising improved stability and simpler manufacturing. However, many labs still rely on low throughput conventional screening methods for nanobody discovery. Here we report streamlined experimental...

William L. White, Edward H. Moseley, Jacqueline M. Tremblay et al. · Journal of Immunology · 0 citations