Leon Franke

A kind of pinky promise: Chain interlocking in the guanidine-II riboswitch observed in atomistic simulations and network analysis.

Riboswitches are dynamic RNA structures that regulate gene expression in response to ligand binding. The guanidine-II riboswitch consists of two hairpin loops, connected by a flexible linker, which can dimerize in the presence of a cognate ligand. Both processes, ligand binding and dimerization, are governed by the fir...