Methyl-CpG-binding domain protein 3 (MBD3) is a member of the methyl-CpG-binding domain (MBD) family, which functions as a scaffold within the nucleosome remodeling and histone deacetylase complex (NuRD). MBD3 has been studied extensively in pluripotency and gene regulation, particularly through chromatin remodeling. E...
Serine/threonine‐protein kinase 10 (STK10), an ERM protein kinase, functions as a membrane–cytoskeleton linker and regulates lymphocyte cortical rigidity, cell shape, adhesion, and migration. Despite its emerging relevance in immune regulation and cancer, the phosphoregulatory mechanisms governing STK10 remain poorly u...
Vaishnavi Gopalakrishnan, Amal Fahma, Althaf Mahin et al.· BioMed Research Internationa...· 0 citations
Unc-51-like autophagy-activating kinase 1 (ULK1), a serine/threonine kinase, is the central regulator of autophagy initiation and plays a crucial role in cellular homeostasis, metabolic adaptation, and stress responses. We performed a large-scale phosphoproteomic data analysis of ULK1 by systematically integrating and...
Furqaan Ahmed Basha, Sreeshma Ravindran Kammarambath, Leona Dcunha et al.· International Journal of Mol...· 0 citations
Background: Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) is a serine/threonine kinase that exhibits oncogenic activity in various cancers. Despite the established role of MAP3K3 in signal transduction, its phosphosignaling landscape, including the mechanisms underlying its activation and the identification...
Findings identify SMG1 as a central phosphorylation hub integrating nonsense-mediated mRNA decay with genome maintenance pathways and provide the first systematic phosphosite-centric framework for understanding its regulation.
Apoorva Pai, Leona Dcunha, Athira Perunelly Gopalakrishnan et al.· Frontiers in Systems Biology· 0 citations
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