Self-Amplifying Oxidative Burst and Antioxidant Collapse Enabled by Redox-Responsive Curcumin-Polyprodrug Nanoplatform for Enhanced Antitumor Therapy
Tumor therapy is challenged by heterogeneity, drug resistance, and systemic toxicity. Targeting tumor redox imbalance using pro-oxidants offers a promising strategy, but natural pro-oxidants such as curcumin (Cur) and cinnamaldehyde (CA) suffer from poor solubility and bioavailability. Here, we developed two redox du...