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Open access Aug 2026

Multifaceted response of microglia in the cuprizone model of demyelination

The cuprizone diet paradigm, which involves selective depletion of oligodendrocytes and subsequent myelin loss, provides an excellent model to study the neuroimmune response to demyelination and remyelination. Microglia, the resident immune cells of the central nervous system, mount a robust response to cuprizone admin...

Ashley Shanahan, Gwenyth C. Eichfeld, Levi Todd et al. · 0 citations
Open access Aug 2026

Aging limits neuronal regeneration from glia in the mouse retina.

Reprogramming resident glia into neurons holds great therapeutic promise for neurodegenerative diseases across the central nervous system, yet these strategies have been developed largely in young animals. Because aging is the primary risk factor for neurodegeneration, whether glia-to-neuron reprogramming remains effec...

Jugasmita Deka, Ying Han, Sucheta Bhattacharya et al. · 0 citations

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