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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Li Chen

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Review Open access Aug 2026

URMylation Signaling Pathway in Cancer: Molecular Mechanisms and Therapeutic Opportunities

Ubiquitin-related modifier 1 (URM1) defines a distinctive ubiquitin-like system in which URM1 functions both as a covalent protein modifier and a sulfur carrier required for wobble uridine (U34) thiolation of cytosolic tRNAs. This dual role places URM1 signaling at the intersection of protein post-translational modific...

Jing-Chao Wang, Pei-Qiang Yan, Wei-Wei Jiang et al. · 0 citations
Open access Aug 2026

Expanding the Ligandable Chemical Space of OTUB1 through Discovery of a Four-Membered-Ring Recruiter Chemotype

Deubiquitinase-targeting chimeras (DUBTACs) have emerged as a promising strategy for targeted protein stabilization, but their broader application remains limited by the scarcity of ligandable deubiquitinase recruiters. Here, we report a previously unexplored four-membered-ring OTUB1 recruiter chemotype. Through system...

Qiong Wu, Xiang-Yang Song, Li Chen et al. · 0 citations

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