Author

Li-Dan Liu

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Open access Sep 2026

Integrated network toxicology and multi-omics profiling reveal cell cycle, DNA damage repair, and metabolic alterations in cyclophosphamide-induced premature ovarian insufficiency

Cyclophosphamide (CTX)-induced chemotherapy injury is a leading iatrogenic cause of premature ovarian insufficiency (POI) and a major barrier to fertility preservation. Yet the systems-level mechanisms underlying its reproductive toxicity remain poorly defined. An integrated network toxicology framework in...

Zhao-Yang Yu, Li-Dan Liu, Xi-Qian Zhang et al. · Frontiers in Pharmacology · 0 citations

Open access Sep 2026

Permissive but not causative: layer-specific LHCGR alterations in ovarian aging

The ovary is among the earliest organs to show clinically consequential age-related decline. The luteinizing hormone/choriogonadotropin receptor (LHCGR) mediates the trophic actions of LH and human chorionic gonadotropin (hCG) in the ovary, and reduced receptor abundance has sometimes been invoked as a possible expla...

Hong-Bo Wu, Zhao Zhang, Li-Yan Huang et al. · npj Aging · 0 citations

Review Open access Jul 2026

Theca cells: active orchestrators of ovarian aging.

This review repositions theca cells as active, bidirectionally regulated participants in ovarian aging-integral to, rather than upstream of, the oocyte-granulosa-theca unit, and proposes theca-specific biomarkers and targeted interventions as priorities for future translational research.

Hong-Bo Wu, Zhao Zhang, Qian-Yi Huang et al. · Reproductive Biology and End... · 0 citations